Anvil Diagnostics — Transforming Fungal Infection Diagnostics

The Clinical Challenge

Invasive fungal infections are hard to detect early

Immunocompromised patients face life-threatening invasive fungal infections with mortality rates in some populations approaching 50% despite treatment. Current diagnostics force clinicians into difficult trade-offs.

Culture is slow

Traditional methods yield results in days to weeks, with poor sensitivity for deep-seated infections.

PCR panels are narrow

Existing PCR tests are fast but cover only a handful of species, missing critical pathogens.

NGS is costly & complex

Next-generation sequencing offers breadth but requires specialized equipment, expertise, and days of turnaround.

MycoScan™

A breakthrough assay

MycoScan is a unique, powerful assay that detects microbial cell-free DNA in plasma. It combines speed, breadth, and accessibility in a single test.

3-hour turnaround

Fast results with a simple process.

Comprehensive

Detect all critical molds, yeasts, and dimorphic fungi with tailored resolution.

Standard dPCR platforms

No specialized sequencing equipment required. Runs on general-purpose hardware already in labs.

Cost-efficient

Simpler and more affordable than NGS while maintaining comprehensive coverage.

Proprietary Technology

Powered by SKIP‑Seq™

Smart Keywords of Informative Primer Sequences

With underlying technology from Rice University, we design compact sets of informative probe-primer "keywords" to profile targeted cfDNA fragments. Each pathogen has a signature combination of keywords across many fragments, and dPCR allows fragments to be measured one molecule at a time.

Our reconstruction algorithm solves for the abundance of the pathogens — multiplexing the information, not the cost. No sequencing required.

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01

Sample

Cell-free DNA extracted from patient plasma

02

Amplify

Informative probe-primer keywords on dPCR

03

Decode

Algorithmic fingerprints identify species & abundance

04

Report

Actionable results in under 3 hours

Panel in development

Pan-fungal coverage

MycoScan maps nearly any fungal pathogen into one of about 30 taxonomic groups, pairing comprehensive inclusivity with tailored taxonomic resolution where it matters. With an overall focus on deep-seated infections, the panel tilts toward molds while still resolving high-priority threats like C. auris.

~30 reported taxonomic groups

40+ species mapped so far

↑ rapidly growing database

Bold indicates taxa reported by MycoScan. Indentations indicate species we have demonstrated inclusivity on so far within the called groups.

Molds

Alternaria / Curvularia spp.
- A. alternata
- C. lunata
Aspergillus calidoustus
Aspergillus flavus
Aspergillus fumigatus
Aspergillus nidulans
Aspergillus niger
Aspergillus terreus
Aspergillus versicolor
Aspergillus spp.
Cladophialophora bantiana
Exophiala / Fonsecaea spp.
- E. dermatitidis
Lomentospora prolificans
Scedosporium spp.
Fusarium spp.
- F. oxysporum
- F. solani
- F. proliferatum
Mucorales
- R. oryzae
- R. microsporus
- R. pusillus
- M. circinelloides
- M. indicus
- L. corymbifera
- C. bertholletiae
- C. blakesleeana
- A. ossiformis
- S. vasiformis

Yeasts

Candida auris
Candida spp.
- C. albicans
- C. haemuli
Cryptococcus spp.
- C. gattii
- C. neoformans
Pneumocystis jirovecii
Trichosporon spp.
- T. asahii
- T. inkin

Mimickers

Legionella spp.
- L. pneumophila
Nocardia spp.

Dimorphics

Blastomyces dermatitidis
Coccidioides spp.
- C. immitis
- C. posadasii
Histoplasma capsulatum
Paracoccidioides spp.
- P. brasiliensis
- P. lutzii
Sporothrix schenckii
Talaromyces spp.
- T. marneffei

Interested in collaboration?

Top institutions have been evaluating a beta version of MycoScan. Reach out to learn more about new collaboration opportunities in 2026.

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Turn cell‑free DNA into clarity